經歷：

■現任

成大醫院牙周病科主任 (2018/08/01-迄今)

臺灣牙周病學會專科醫師 (1993/06-迄今)

美國牙周病國家專科醫師 (2006/12-迄今)

■曾任

成大醫院牙周病科主任 (2004/03-2017/07)

美國南加州大學博士後研究 (2006/08-2007/08)

成大醫學院口醫所教授 (2014/08-2017/07)

研究成果：

■Original Papers

1.  *Hom-Lay Wang, Kuo Yuan, Frederick Burgett, Yu Shyr, Salam Syed. (1994) Adherence of oral microorganisms to guided tissue membranes: An in vitro study. J Periodontol ; 65: 211-218.
2.  Guin-Chin Tsai, Chuen-Chi Tseng, Kuo Yuan, Chi-Chou Huang. (1994) Current status of the removal of pocket epithelium. J Dent Sci; 15: 142-146.
3.  *Chuen-Chyi Tseng, Wei-Meei Harn, Yea-Huey Melody Chen, Chi-Chou Huang, Kuo Yuan, Ping-Hsien Huang. (1996) A new approach to the treatment of true-combined endodontic-periodontic lesions by the guided tissue regeneration technique. J Endodont; 22: 693-696.
4.  Kuo Yuan, Chuen-Chyi Tseng, Chi-Chou Huang. (1996) Bioresorbable membranes in guided tissue regeneration: updated literature review. J Dent Sci; 16: 115-120.
5.  Huch Lee, Chuen-Chyi Tseng, Kuo Yuan, Chi-Chou Huang. (1996) Papilla preservation technique—a revisit. Chin J Periodontol; 1:84-89.
6.  Pei-Ju Lin, Chuen-Chyi Tseng, Kuo Yuan. (1996) The clinical application of ultrasonic scaling instrument. Chin J Periodontol ; 1:58-63.
7.  Chi-Chou Huang, Chuen-Chyi Tseng, Kuo Yuan. (1996) Ridge preservation and augmentation using guided tissue regeneration immediately after tooth extraction—A case report. Chin J Periodontol; 1: 64-69.
8.  Kuo Yuan, Chuen-Chyi Tseng, Chi-Chou Huang. (1997) Apical infection associated with an ectopic calculus—Case Report. Chin J Periodontol; 2:217-223.
9.  *Chuen-Chyi Tseng, Kuo Yuan, Wen-Li Wang, Yea-Huey Melody Chen, Chi-Chou Huang. (1997) Simultaneous team approach of a crown-lengthening procedure and an operative restoration: technique and long-term effect. Quintessence Int; 28: 249-254
10.  Guin-Chin Tsai, Chuen-Chyi Tseng, Kuo Yuan, Chi-Chou Huang. (1998) The application of ultrasonic scalers and modified ultrasonic scalers on periodontal therapy. Chin J Periodontol; 3:131-143.
11.  Chuen-Chyi Tseng, Kuo Yuan, Jehn-Shyun Huang, Chong-Shan Wang, Min-Jye Wen. (1998) Oral health condition and treatment needs of volunteer residents in Alein Area. Chin J Periodontol; 3:153-158.
12.  Chuen-Chyi Tseng, Kuo Yuan, Chi-Chou Huang. (1998) Surgical correction of an early exposed membrane during a guided bone regeneration procedure: technique and case reports. Chin J Periodontol; 3: 25-33
13.  *Wei-Mei Harn, YH Chen, Kuo Yuan, CH Chung, PH Huang. Calculus-like deposit at apex of tooth with refractory apical periodontitis. (1998) Endodontics & Dental Traumatology; 14:237-40.
14.  Chuen-Chyi Tseng, Chi-Chou Huang, Kuo Yuan.(1999) Current status and clinical application of Atribsorb absorbable regeneration material. Chin J Periodontol ;4: 97-103.
15.  *Kuo Yuan, Ping-Chi Hsu, Chuen-Chyi Tseng, Jen-Ren Wang. (2001) Detection rate of Actinobacillus actinomycetemcomitans on the permanent first molars of primary school children in Taiwan by polymerase chain reaction. J Clin Periodontol;28:348-352. (NSC 87-2314-B-006-051)
16.  *Kuo Yuan, Chih-Jen Chang, Chuen-Chyi Tseng, Jen-Ren Wang. (2001) Detection of putative periodontal pathogens in non-insulin-dependent diabetes mellitus by polymerase chain reaction. J Periodontal Res;36:18-24. (NSC 87-2314-B-006-051)
17.  *Kuo Yuan, Ying-Tai Jin, Ming T. Lin. (2000) Expression of Tie-2, angiopoietin-1, angiopoietin-2, ephrin-B2, Eph-B4 in pyogenic granuloma of human gingiva implicates their roles in inflammatory angiogenesis. J Periodontal Res; 35:165-171. (NSC 85-2314-B-006-123)
18.  *Kuo Yuan, Ying-Tai Jin, Ming T. Lin. (2000) The detection and comparison of angiogenesis-associated factors in pyogenic granuloma by immunohistochemistry. J Periodontol; 71:701-709. (NSC 88-2314-B-006-184)
19.  *Kuo Yuan, Lih-Yuh C. Wing, Ming T. Lin. Pathogenetic roles of angiogenic factors in pregnancy tumors are modulated by female sex hormones. (2002) J Periodontol;73:701-708. (NSC 89-2314-B-006-184)
20.  *Kuo Yuan, J-Liang Chen, Ming T. Lin. (2003) Enamel matrix derivative exhibit angiogenic effect in vitro and in a murine model. J Clin Periodontol;30:732-738. (NSC 90-2314-B-006-127)
21.  Chia-Wen Hsu, Kuo Yuan, Chuen-Chyi Tseng. (2002) A mimic autogenous bone graft: PepGen P-15. Chinese Journal of Periodontology;6:255-260.
22.  Jia-Kuang Liu, Shu-Fen Chuang, Tung-Yiu Wong, Kuo Yuan, Chuan-Yang Chang. (2002) Esthectic consideration for anterior tooth position. J Taiwan Assoc Ortho 14(1):28-33.
23.  Kuo-Ching Huang, Ta-Hsiung Chou, Kuo Yuan, Chuen-Chyi Tseng (2002) The relationship of IL-1 gene polymorphism and periodontal disease—Literature review. Chin J Periodontol 7: 169-176.
24.  *Kuo Yuan, Ming T. Lin. (2004) The roles of vascular endothelial growth factor  and angiopoietin-2 in the regression of pregnancy pyogenic granuloma. Oral Diseases;10:179-185. (NSC 91-2314-B-006-042)
25.  *Kuo Yuan, Tse-Ming Hong, Jeremy J.W. Chen, Ming T. Lin. (2004) Syndecan-1 upregulated by ephrinB2/EphB4 play dual roles in inflammatory angiogenesis. Blood;104:1025-1033 (NSC 91-2314-B-006-042)
26.  Hui-Hua Chen, Chuen-Den Tseng, Kuo Yuan, Chuen-Chyi Tseng (2005) Current status on the relationship between periodontal disease and cardiovascular disease. Chin J Periodontol; 10:77-79.
27.  Te-Chun Liu, Chyan-Yang Chang, Kuo Yuan, Chia-Yi Pan, Wei-Yung Hsu, Jia-Kuang Liu. (2005) Gingival recession related to orthodontic treatment-Review article. J Taiwan Assoc Ortho 17(4):51-56.
28.  *Kuo Yuan, Chia-Wen Hsu, Wan-Hua Tsai (2006) The induction and possible subsequent effect of human antibodies against porcine enamel matrix derivative. J Periodontol; 77: 1355-1361.
29.  Shih-Bin Yang, Kuo Yuan, Chuen-Chyi Tseng (2007) The exploration of Bio-Oss in the application of periodontal and osseous regeneration. Chin J Periodontol; 12:53-69. 
30.  Chih-Wen Tseng, Kuo Yuan, Chuen-Chyi Tseng (2007) The application of Er:YAG in periodontal treatment-- a literature review. Chin J Periodontol; 12:83-97, 2007.
31.  *Kuo Yuan, Jehn-Shyun Huang, Chia-Wen Hsu, I-Jen Hung (2007) A mineralization-associated membrane protein plays a role in the biological functions of the peptide-coated bovine hydroxyapatite. J Periodontal Res; 42:420-428.
32.  *Chia-Wen Hsu, Kuo Yuan, Chuen-Chyi Tseng (2009) The negative effect of platelet-rich plasma on human cells is associated with secreted thrombospondin-1. Oral Surg Oral Med Oral Pathol Endodont;107:185-192.
33.  Shih-Chung Liao, Ming-Ko Li, Kuo Yuan, Ju-Chun FanChiang, Chuen-Chyi Tseng (2009) A case report and literature review of maxillary sinus floor elevation with lateral window technique. J Taiwan Periodontol;14: 113-124.
34.  *Po-Chen Hsieh, Yiang-Tai Jin, Chia-Wen Chang, Chi-Chou Huang, Shih-Chung Liao, Kuo Yuan (2010) Elastin in oral connective tissue modulates the keratinization of overlying epithelium. J Clin Periodontol;37:705-711. (NSC 98-2314-B-006-032). 
35.  *Kuo Yuan, Tzer-Min Lee, Jehn-Shyun Huang (2010) Temporomandibular joint reconstruction: from alloplastic prosthesis to bioengineering tissue. Journal of Medical and Biological Engineering;30(2): 65-72.
36.  Tzu-Yuan Hung, Chuen-Chyi Tseng, Kuo Yuan (2010) Current status of mesenchymal stem cells in periodontal regenerative therapy—literature review. J Taiwan Periodontol 15:293-301.
    Shih-Chung Liao, Po-Chen Hsieh, Jehn-Shyun Huang, Chia-Wen Hsu, Kuo Yuan (2012) Aberrant Keratinization of Reticular Oral Lichen Planus is Related to Elastolysis. Oral Surgery Oral Medicine Oral Pathol Endodont 113(6):808-16
37.  *Tzu-Yuan Hung, Hsiang-Chun Lin, Ying-Jen Chan, Kuo Yuan (2012) Isolating stromal stem cells from periodontal granulation tissues. Clinical Oral Investigations 16(4): 1171-1180.
38.  *Kuo Yuan, Ken-Chung Chen, Ying-Jen Chan, Chun-Chun Tsai, Hui-Hwa Chen, Chien-Chi Shih (2012) Dental implant failure associated with bacterial infection and long-term bisphosphonate usage: a case report. Implant Dentistry 21:3-7.
39.  *Kuan-Chen Kung, Kuo Yuan, Tzer-Min Lee, Truan-Sheng Lui (2012). Effect of heat treatment on microstructures and mechanical behavior of porous Sr-Ca-P coatings on titanium. Journal of Alloys and Compounds 515(2):68-73.
40.  Hsuan Lung, Shih-Chung Liao, Kuo Yuan, Chuen-Chyi Tseng (2012) Interdental and inter-implant papilla: Literature review and management. J Taiwan Periodontol 17:99-109.
41.  *Kuan-Liang Chen, Yu-Yuan Huang, Jrhau Lung, Ying-Yi Yeh, Kuo Yuan (2013) CD44 is involved in mineralization of dental pulp cells. Journal of Endodontics 39:351–356.
42.  *Ping Wu, Xiaoshan Wu, Ting-Xin Jiang, Ruth Elsey, Bradley L Temple, Stephen J Divers, Travis Glenn, Kuo Yuan, Min-Huey Chen, Randall Widelitz, Cheng-Ming Chuong (2013) Tooth renewal in alligator: specialized stem cell niche is associated with repetitive renewal of a complex organ. Proc Natl Acad Sci U S A 110(22):E2009-2018.
43.  *Jenn-Rong Yang, Chia-Wen Hsu, Shih-Chung Liao,Yu-Ting Lin, Lih-Ren Chen, Kuo Yuan (2013).Transplantation of embryonic stem cells enhances regeneration of periodontal furcation defects in a porcine model. Journal of Clinical Periodontology 40:364-371.
44.  Yi-Chun Lin, Hsiu-Ming Hsu, Chiang-Shin Liu, Kuo Yuan (2014). A peripheral ameloblastic fibro-odontoma in a 3-year-old girl: case report and immunohistochemical analysis. Case Reports in Dentistry, Vol (2014), Article ID 321671, 6 pages. http://dx.doi.org/10.1155/2014/321671
45.  *Kuo Yuan, Ying-Jen Chan, Kuan-Chen Kung, Tzer-Min Lee (2014) Comparison of the osseointegration on different implant surfaces after bacterial contamination and cleaning: a rabbit study. International Journal of Oral and Maxillofacial Implants 29(1):32-40.
46.  *Hsiang-Chun Lin, Chao-Liang Wu, Yuh-Ling Chen, Jehn-Shyun Huang, Tung-Yiu Wong, Kuo Yuan (2014). High-Level β1-Integrin Expression in a Subpopulation of Highly Tumorigenic Oral Cancer Cells. Clinical Oral Investigations 18(4):1277-1284.
47.  *Ying-Yi Yeh, Yu-Chi Yang, and Kuo Yuan (2014). Importance of CD44 in the proliferation and mineralization of periodontal ligament cells. Journal of Periodontal Research 49(6):827-35.
48.  Yu-Jing Liao, Chia-Hsin Liao, Jiunn-Wang Liao, Kuo Yuan, Yu-Zhan Liu, Yi-Shiou Chen, Lih-Ren Chen, Jenn-Rong Yang (2014) Establishment and characterization of novel porcine induced pluripotent stem cells expressing hrGFP. Journal of Stem Cell Research & Therapy 4: 208. doi:10.4172/2157-7633.1000208.
49.  Ming-Shyue Chiang, Shih-Pin Yang, Kuo Yuan, Chuen-Chyi Tseng (2014) Periodontal regenerative therapy for severe combined perio-endo lesions: a comprehensive periodontal case report. J Taiwan Periodontol 19(2):136-154.
50.  Chia-Hsin Liao, Yu-Jing Liao, Kuo Yuan, Yu-Chi Yang, Yu-Yu Joyce HO, Jiunn-Wang Liao, Lih-Ren Chen, Yow-Ling Shiue, and Jenn-Rong Yang (2014) The pro-inflammatory cytokines expression of porcine embryonic stem cells xenotransplanted into the brain and spinal cord in rats. Journal of Cell Science & Therapy 5:168. doi:10.4172/2157-7013.1000168.
51.  Wei-Yui Huang, Chi-Chung Hsu, Kuo Yuan, Chuen-Chyi Tseng (2014) Epithelial stem cells in the gingiva—a literature review. J Taiwan Periodontol 19(3):205 -213.
52.  Chun-Chun Tsai, Kuo Yuan, Chuen-Chyi Tseng (2014). Implant overload: a literature review. J Taiwan Periodontol 19(4):287-295.
53.  *Ming-Shyue Chiang, Jenn-Rong Yang, Shih-Chung Liao, Chi-Chung Hsu,  Chia-Wen Hsu, Kuo Yuan (2015) Latent transforming growth factor-β binding proteins (LTBP-1 and LTBP-2) and gingiva keratinization. Oral Diseases 21(6):762-769.
54.  Cheng-Chung Hsu, Kuo Yuan, Chuen-Chyi Tseng (2015) The effect of strontium on osseointegration of dental implant: a literature review. J Taiwan Periodontol, 20(3):194-202.
55.  *Kuan-Liang Chen, Ying-Yi Yeh, Jrhau Lung, Yu-Chi Yang, Kuo Yuan (2016) Mineralization effect of hyaluronan on dental pulp cells via CD44. Journal of Endodontics 42 (5):711-716.
56.  Meng-Feng Wu, Tzer-Min Lee, Kuo Yuan, Chuen-Chyi Tseng (2016) The osseointegration of nano-structured implants. A literature review. J Taiwan Periodontol, 21(4):359-371 (2017牙周病學會最佳論文).
57.  Chin-Chung Hsu, Kuo Yuan, Chuen-Chyi Tseng (2016) The application of enamel matrix derivatives on root coverage. A literature review. J Taiwan Periodontol, 21(4):394-405 (2017牙周病學會最佳論文).
58.  Ching-Chih Huang, Kuo Yuan, Chuen-Chi Tseng (2017) A brief introduction of periodontal regeneration. J Taiwan Periodontol, 22(3):224-236, 2017.
59.  張盈盈,曾春祺,袁國, 郭家銘,許嘉文。牙周暨植體現況報導: 系列之十三: 富含血小板血漿(PRP) 在牙周軟硬組織的應用. 臺灣牙周醫誌，22(Suppl 1):S251-268, 2017
60.  柯俞靖，袁國，曾春祺。 牙周暨植體現況報導: 系列之二十一: 牙周暨植體的維護治療。臺灣牙周醫誌，22(Suppl 1):S363-370, 2017。
61.  Ying-Ying Chang, Chih-Wen Tseng, Kuo Yuan (2018) Severe Gingival Ulceration and Necrosis Caused by an Antithyroid Drug: One Case Report and Proposed Clinical Approach. Clin Adv Periodontics, 8:11–16.
62.  Shin-Chen Pan, Che-Yu Li, Chia-Yi Kuo, Yi-Zih Kuo, Wei-Yu Fang, Yu-Hsuan Huang, Tzu-Chin Hsieh, Hung-Ying Kao, Kuo Yuan, Ya-Rong Kang, Wan-Chi Tsai, Sen-Tien Tsai, Li-Wha Wu (2018). The p53-S100A2 positive feedback loop negatively regulates epithelialization in cutaneous wound healing. Sci Rep. 2018 Apr 3;8(1):5458. doi:10.1038/s41598-018-23697-5.
63.  Kuang-Tse Lo, Jenn-Rong Yang, Kuo Yuan (2019) Potential application of iPSC on cell-based periodontal therapy. Journal of Periodontics and Implant Dentistry 24(1) :8-16.
I-    Chun Chen, Chih-Chung Hsu, Cheng-Kun Tai, Kuo Yuan, Chuen-Chyi Tseng (2019). Esthetic and Prosthetic Consideration of Crown Lengthening Procedure in Altered Passive Eruption: Case report. Journal of Periodontics and Implant Dentistry 24(2): 134 - 145.

成大醫院 台南總院