經歷：

■現任

2019年中華民國牙醫師公會全聯會教育學術類特殊貢獻獎

成大醫院口腔顎面外科主任

成大口腔醫學研究所所長

成大醫院口腔醫學部（牙科）主任

中華民國口腔顎面外科學會理事長

中華民國口腔顎面外科學會專科醫師、訓練指導醫師

美國維吉尼亞醫學院研究

台大醫院兼任主治醫師

研究成果：

■Referred Papers (since 2011)

1.Chen, M.Y., Chen, J.W., Wu, L.W., Huang, K.C., Chen, J.Y., Wu, W.S., Chiang, W.F., Shih, C.J., Tsai, K.N., Hsieh, W.T., Ho, Y.H., Wong, T.Y., Wu, J.H., Chen, Y.L. Carcinogenesis of Male Oral Submucous Fibrosis Alters Salivary Microbiomes (2021) Journal of Dental Research, 100 (4), pp. 397-405.

2.Hsiao, J.-R., Lee, W.-T., Ou, C.-Y., Huang, C.-C., Chang, C.-C., Tsai, S.-T., Chen, K.-C., Huang, J.-S., Wong, T.-Y., Lai, Y.-H., Wu, Y.-H., Hsueh, W.-T., Wu, S.-Y., Yen, C.-J., Chang, J.-Y., Lin, C.-L., Weng, Y.-L., Yang, H.-C., Chen, Y.-S., Chang, J.S. Validation of Alcohol Flushing Questionnaire to Identify ALDH2 Status in a Case–Control Study of Head and Neck Cancer (2019) Alcoholism: Clinical and Experimental Research, 43 (6), pp. 1225-1233.

3.Chen, K.-C., Huang, J.-S., Chen, M.-Y., Cheng, K.-H., Wong, T.-Y., Huang, T.-T. Unusual Supernumerary Teeth and Treatment Outcomes Analyzed for Developing Improved Diagnosis and Management Plans (2019) Journal of Oral and Maxillofacial Surgery, 77 (5), pp. 920-931.

4.Huang, T.-T., Chen, K.-C., Wong, T.-Y., Chen, C.-Y., Chen, W.-C., Chen, Y.-C., Chang, M.-H., Wu, D.-Y., Huang, T.-Y., Nioka, S., Chung, P.-C., Huang, J.-S. Two-channel autofluorescence analysis for oral cancer (2019) Journal of Biomedical Optics, 24 (5), art. no. 051402.

5.Nguyen, T.M.T., Wang, P.-W., Hsu, H.-M., Cheng, F.-Y., Shieh, D.-B., Wong, T.-Y., Chang, H.-J. Dental cement's biological and mechanical properties improved by ZnO nanospheres (2019) Materials Science and Engineering C, 97, pp. 116-123.

6.Chang, C.-C., Lee, W.-T., Hsiao, J.-R., Ou, C.-Y., Huang, C.-C., Tsai, S.-T., Chen, K.-C., Huang, J.-S., Wong, T.-Y., Lai, Y.-H., Wu, Y.-H., Hsueh, W.-T., Wu, S.-Y., Yen, C.-J., Chang, J.-Y., Lin, C.-L., Weng, Y.-L., Yang, H.-C., Chen, Y.-S., Chang, J.S. Oral hygiene and the overall survival of head and neck cancer patients (2019) Cancer Medicine, 8 (4), pp. 1854-1864.

7.Lee, W.-T., Hsiao, J.-R., Ou, C.-Y., Huang, C.-C., Chang, C.-C., Tsai, S.-T., Chen, K.-C., Huang, J.-S., Wong, T.-Y., Lai, Y.-H., Wu, Y.-H., Hsueh, W.-T., Wu, S.-Y., Yen, C.-J., Chang, J.-Y., Lin, C.-L., Weng, Y.-L., Yang, H.-C., Chen, Y.-S., Chang, J.S. The influence of prediagnosis alcohol consumption and the polymorphisms of ethanol-metabolizing genes on the survival of head and neck cancer patients (2019) Cancer Epidemiology Biomarkers and Prevention, 28 (2), pp. 248-257.

8.Huang, T.T., Cheng, K.H., Chang, C.J., Chen, K.C., Liu, J.K., Wong, T.Y. Transoral vertical ramus osteotomy fixed with Kirschner pins (2018) British Journal of Oral and Maxillofacial Surgery, 56 (9), pp. 841-846.

9.Ye, M.-Y., Chen, M.-Y., Chang, Y.-H., Huang, J.-S., Huang, T.-T., Wong, T.-Y., Hong, T.-M., Chen, Y.-L. Growth-regulated oncogene-α from oral submucous fibrosis fibroblasts promotes malignant transformation of oral precancerous cells (2018) Journal of Oral Pathology and Medicine, 47 (9), pp. 880-886.

10.Hsiao, J.-R., Chang, C.-C., Lee, W.-T., Huang, C.-C., Ou, C.-Y., Tsai, S.-T., Chen, K.-C., Huang, J.-S., Wong, T.-Y., Lai, Y.-H., Wu, Y.-H., Hsueh, W.-T., Wu, S.-Y., Yen, C.-J., Chang, J.-Y., Lin, C.-L., Weng, Y.-L., Yang, H.-C., Chen, Y.-S., Chang, J.S. The interplay between oral microbiome, lifestyle factors and genetic polymorphisms in the risk of oral squamous cell carcinoma (2018) Carcinogenesis, 39 (6), pp. 778-787.

11.Wong, T.-Y., Liu, J.-K., Wu, T.-C., Tu, Y.-H., Chen, K.-C., Fang, J.-J., Cheng, K.-H., Lee, J.-W. Plane-to-plane analysis of mandibular misalignment in patients with facial asymmetry (2018) American Journal of Orthodontics and Dentofacial Orthopedics, 153 (1), pp. 70-80.

12.Huang, C.-C., Hsiao, J.-R., Lee, W.-T., Lee, Y.-C., Ou, C.-Y., Chang, C.-C., Lu, Y.-C., Huang, J.-S., Wong, T.-Y., Chen, K.-C., Tsai, S.-T., Fang, S.-Y., Wu, J.-L., Wu, Y.-H., Hsueh, W.-T., Yen, C.-J., Wu, S.-Y., Chang, J.-Y., Lin, C.-L., Wang, Y.-H., Weng, Y.-L., Yang, H.-C., Chen, Y.-S., Chang, J.S. Investigating the Association between Alcohol and Risk of Head and Neck Cancer in Taiwan (2017) Scientific Reports, 7 (1), art. no. 9701.

13.Huang, T.-T., Huang, J.-S., Wang, Y.-Y., Chen, K.-C., Wong, T.-Y., Chen, Y.-C., Wu, C.-W., Chan, L.-P., Lin, Y.-C., Kao, Y.-H., Nioka, S., Yuan, S.-S.F., Chung, P.-C. Novel quantitative analysis of autofluorescence images for oral cancer screening (2017) Oral Oncology, 68, pp. 20-26.

14.Lin, C.-L., Lee, W.-T., Ou, C.-Y., Hsiao, J.-R., Huang, C.-C., Huang, J.-S., Wong, T.-Y., Chen, K.-C., Tsai, S.-T., Fang, S.-Y., Huang, T.-T., Wu, J.-L., Wu, Y.-H., Hsueh, W.-T., Yen, C.-J., Lai, Y.-H., Liao, H.-C., Wu, S.-Y., Yang, M.-W., Lin, F.-C., Chang, J.-Y., Wang, Y.-H., Weng, Y.-L., Yang, H.-C., Chen, Y.-S., Chang, J.S. Regular recreational physical activity and risk of head and neck cancer (2017) BMC Cancer, 17 (1), art. no. 286.

15.Chang, C.-C., Lee, W.-T., Lee, Y.-C., Huang, C.-C., Ou, C.Y., Lin, Y.-H., Huang, J.-S., Wong, T.-Y., Chen, K.-C., Hsiao, J.-R., Lu, Y.-C., Tsai, S.-T., Lai, Y.-H., Wu, Y.-H., Hsueh, W.-T., Yen, C.-J., Wu, S.-Y., Chang, J.-Y., Fang, S.-Y., Wu, J.-L., Lin, C.-L., Weng, Y.-L., Yang, H.-C., Chen, Y.-S., Chang, J.S. Investigating the association between diet and risk of head and neck cancer in Taiwan (2017) Oncotarget, 8 (58), pp. 98865-98875.

16.Wu, Y.-H., Yen, C.-J., Hsiao, J.-R., Ou, C.-Y., Huang, J.-S., Wong, T.-Y., Tsai, S.-T., Huang, C.-C., Lee, W.-T., Chen, K.-C., Fang, S.-Y., Wu, J.-L., Hsueh, W.-T., Lin, F.-C., Yang, M.-W., Chang, J.-Y., Liao, H.-C., Wu, S.-Y., Lin, C.-L., Wang, Y.-H., Weng, Y.-L., Yang, H.-C., Chen, Y.-S., Chang, J.S. A comprehensive analysis on the association between tobacco-free betel quid and risk of head and neck cancer in Taiwanese men (2016) PLoS ONE, 11 (10), art. no. 0164937.

17.Liao, H.-C., Wu, S.-Y., Ou, C.-Y., Hsiao, J.-R., Huang, J.-S., Tsai, S.-T., Huang, C.-C., Wong, T.-Y., Lee, W.-T., Chen, K.-C., Fang, S.-Y., Wu, J.-L., Huang, T.-T., Wu, Y.-H., Hsueh, W.-T., Yen, C.-J., Yang, M.-W., Lin, F.-C., Lai, Y.-H., Chang, J.-Y., Lin, C.-L., Wang, Y.-H., Weng, Y.-L., Yang, H.-C., Chen, Y.-S., Chang, J.S. Allergy symptoms, serum total immunoglobulin E, and risk of head and neck cancer (2016) Cancer Causes and Control, 27 (9), pp. 1105-1115.

18.Fang, J.-J., Tu, Y.-H., Wong, T.-Y., Liu, J.-K., Zhang, Y.-X., Leong, I.-F., Chen, K.-C. Evaluation of mandibular contour in patients with significant facial asymmetry (2016) International Journal of Oral and Maxillofacial Surgery, 45 (7), pp. 922-931.

19.Kuo, R.-F., Chen, S.-J., Wong, T.-Y., Lu, B.-C., Huang, Z.-H. Digital morphology comparisons between models of conventional intraoral casting and digital rapid prototyping (2015) IFMBE Proceedings, 46, pp. 478-480.

20.Lee, W.-T., Huang, C.-C., Chen, K.-C., Wong, T.-Y., Ou, C.-Y., Tsai, S.-T., Yen, C.-J., Fang, S.-Y., Lo, H.-I., Wu, Y.-H., Hsueh, W.-T., Yang, M.-W., Lin, F.-C., Hsiao, J.-R., Huang, J.-S., Chang, J.-Y., Chang, K.-Y., Wu, S.-Y., Lin, C.-L., Wang, Y.-H., Weng, Y.-L., Yang, H.-C., Chang, J.S. Genetic polymorphisms in the prostaglandin pathway genes and risk of head and neck cancer (2015) Oral Diseases, 21 (2), pp. 207-215.

21.Chen, K.-C., Hsueh, W.-T., Ou, C.-Y., Huang, C.-C., Lee, W.-T., Fang, S.-Y., Tsai, S.-T., Huang, J.-S., Wong, T.-Y., Wu, J.-L., Yen, C.-J., Wu, Y.-H., Lin, F.-C., Yang, M.-W., Chang, J.-Y., Liao, H.-C., Wu, S.-Y., Hsiao, J.-R., Lin, C.-L., Wang, Y.-H., Weng, Y.-L., Yang, H.-C., Chen, Y.-S., Chang, J.S. Alcohol drinking obliterates the inverse association between serum retinol and risk of head and neck cancer (2015) Medicine (United States), 94 (26), art. no. e1064.

22.Shiah, S.-G., Hsiao, J.-R., Chang, W.-M., Chen, Y.-W., Jin, Y.-T., Wong, T.-Y., Huang, J.-S., Tsai, S.-T., Hsu, Y.-M., Chou, S.-T., Yen, Y.-C., Jiang, S.S., Shieh, Y.-S., Chang, I.-S., Hsiao, M., Chang, J.-Y. Downregulated miR329 and miR410 promote the proliferation and invasion of oral squamous cell carcinoma by targeting Wnt-7b (2014) Cancer Research, 74 (24), pp. 7560-7572.

23.Huang, C.-C., Lee, W.-T., Tsai, S.-T., Ou, C.-Y., Lo, H.-I., Wong, T.-Y., Fang, S.-Y., Chen, K.-C., Huang, J.-S., Wu, J.-L., Yen, C.-J., Hsueh, W.-T., Wu, Y.-H., Yang, M.-W., Lin, F.-C., Chang, J.-Y., Chang, K.-Y., Wu, S.-Y., Hsiao, J.-R., Lin, C.-L., Wang, Y.-H., Weng, Y.-L., Yang, H.-C., Chang, J.S. Tea consumption and risk of head and neck cancer (2014) PLoS ONE, 9 (5), art. no. e96507.

24.Lin, H.-C., Wu, C.-L., Chen, Y.-L., Huang, J.-S., Wong, T.-Y., Yuan, K. High-level β1-integrin expression in a subpopulation of highly tumorigenic oral cancer cells (2014) Clinical Oral Investigations, 18 (4), pp. 1277-1284.

25.Wong, T.-Y., Liu, J.-K., Fang, J.-J., Wu, T.-C., Tu, Y.-H. Use of the matching optimal symmetry plane method in planning surgical correction of facial asymmetry - A preliminary report of 20 patients (2014) Journal of Oral and Maxillofacial Surgery, 72 (6), pp. 1180.e1-1180.e13.

26.Tsai, S.-T., Wong, T.-Y., Ou, C.-Y., Fang, S.-Y., Chen, K.-C., Hsiao, J.-R., Huang, C.-C., Lee, W.-T., Lo, H.-I., Huang, J.-S., Wu, J.-L., Yen, C.-J., Hsueh, W.-T., Wu, Y.-H., Yang, M.-W., Lin, F.-C., Chang, J.-Y., Chang, K.-Y., Wu, S.-Y., Liao, H.-C., Lin, C.-L., Wang, Y.-H., Weng, Y.-L., Yang, H.-C., Chang, J.S. The interplay between alcohol consumption, oral hygiene, ALDH2and ADH1B in the risk of head and neck cancer (2014) International Journal of Cancer, 135 (10), pp. 2424-2436.

27.Chang, J.S., Lo, H.-I., Wong, T.-Y., Huang, C.-C., Lee, W.-T., Tsai, S.-T., Chen, K.-C., Yen, C.-J., Wu, Y.-H., Hsueh, W.-T., Yang, M.-W., Wu, S.-Y., Chang, K.-Y., Chang, J.-Y., Ou, C.-Y., Wang, Y.-H., Weng, Y.-L., Yang, H.-C., Wang, F.-T., Lin, C.-L., Huang, J.-S., Hsiao, J.-R. Investigating the association between oral hygiene and head and neck cancer (2013) Oral Oncology, 49 (10), pp. 1010-1017.

28.Chiu, L.-F., Huang, P.-Y., Chiang, W.-F., Wong, T.-Y., Lin, S.-H., Lee, Y.-C., Shieh, D.-B. Oral cancer diagnostics based on infrared spectral markers and wax physisorption kinetics (2013) Analytical and Bioanalytical Chemistry, 405 (6), pp. 1995-2007.

29.Hsiao, J.-R., Ou, C.-Y., Lo, H.-I., Huang, C.-C., Lee, W.-T., Huang, J.-S., Chen, K.-C., Wong, T.-Y., Tsai, S.-T., Yen, C.-J., Wu, Y.-H., Hsueh, W.-T., Yang, M.-W., Wu, S.-Y., Chang, J.-Y., Chang, K.-Y., Lin, C.-L., Wang, F.-T., Wang, Y.-H., Weng, Y.-L., Yang, H.-C., Chang, J.S. Allergies and Risk of Head and Neck Cancer: An Original Study plus Meta-Analysis (2013) PLoS ONE, 8 (2), art. no. e55138.

30.Kuo, T.-H., Wong, T.-Y., Wu, T.-C., Fang, J.-J. Optical tracking-based model surgery for orthognathic surgical planning using a quantifying evaluation method (2012) IEEE Transactions on Information Technology in Biomedicine, 16 (6), art. no. 6287023, pp. 1193-1199.

31.Lee, Y.-C., Wong, T.-Y., Shieh, S.-J., Lee, J.-W. Trismus release in oral cancer patients (2012) Annals of Plastic Surgery, 69 (6), pp. 598-601.

32.Huang, Y.-W., Chang, C.-H., Wong, T.-Y., Liu, J.-K. Bone stress when miniplates are used for orthodontic anchorage: Finite element analysis (2012) American Journal of Orthodontics and Dentofacial Orthopedics, 142 (4), pp. 466-472.

33.Liu, T.-C., Chang, C.-H., Wong, T.-Y., Liu, J.-K. Finite element analysis of miniscrew implants used for orthodontic anchorage (2012) American Journal of Orthodontics and Dentofacial Orthopedics, 141 (4), pp. 468-476.

34.Fan, L.-C., Chiang, W.-F., Liang, C.-H., Tsai, Y.-T., Wong, T.-Y., Chen, K.-C., Hong, T.-M., Chen, Y.-L. α-Catulin knockdown induces senescence in cancer cells (2011) Oncogene, 30 (23), pp. 2610-2621.

成大醫院 台南總院

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