經歷：

■現任

成大醫院口腔診斷及一般牙科主任(2001/02-迄今)

成大醫院主治醫師(2000/08-迄今)

國立成功大學牙醫系暨口腔醫學研究所 講座教授(2021/01-迄今)

成大國際巨分子與奈米醫學創新研發中心主任(2013/04-迄今)

口腔病理科專科醫師

■曾任

科技部政務次長(2018/09-2020/12)

成大醫學院特聘教授兼科主任兼研究所所長(2011/08-2014/01)

國立成功大學口腔醫學研究所 特聘教授(2011/08-2020/07)

成大微奈米科技研究中心特聘研究員(2010/01-2012/12)

成大醫學院教授兼科主任兼研究所所長(2009/08-2011/07)

成大醫學院教授(2008/08-2011/07)

成大研究發展處企劃組組長(2007/02-2009/08)

成大微奈米科技研究中心研究教育組組長(2005/10-2007/01)

成大醫學院副教授(2005/08-2008/07)

成大醫學院助理教授(1999/02-2005/07)

美國麻州布萊根婦女醫院口腔病理學研究員(1993/09-1999/01)

美國哈佛大學牙醫學院研究員(1991/09-1997/06)

台北榮總醫院牙科部住院醫師(1988/08-1991/07)

口腔診斷暨病理專科醫師

家庭牙科專科醫師

研究成果：

■Original Papers (past five years)

1. Asare-Werehene M, Nakka K, Reunov A, Chiu CT, Lee WT, Abedini MR, Wang PW, Shieh DB, Dilworth FJ, Carmona E, Le T, Mes-Masson AM, Burger D, Tsang BK. (2020) The exosome-mediated autocrine and paracrine actions of plasma gelsolin in ovarian cancer chemoresistance. Oncogene. 2020 Feb;39(7):1600-1616.

2. Yang LX, Wu YN, Wang PW, Su WC, Shieh DB. (2019 Sep) Iron Release Profile of Silica-Modified Zero-Valent Iron NPs and Their Implication in Cancer Therapy. Int J Mol Sci. 2019 Sep 4;20(18).

3. Yen CL, Liao YC, Chen RF, Huang YF, Chung WC, Lo PC, Chang CF, Wu PC, Shieh DB, Jiang ST, Shieh CC. (2019 May) Targeted Delivery of Curcumin Rescues Endoplasmic Reticulum-Retained Mutant NOX2 Protein and Avoids Leukocyte Apoptosis. J Immunol. pii: ji1801599. doi: 10.4049/jimmunol.1801599.

4. Chen YH, Li TJ, Tsai BY, Chen LK, Lai YH, Li MJ, Tsai CY, Tsai PJ, Shieh DB. (2019 May) Vancomycin-Loaded Nanoparticles Enhance Sporicidal and Antibacterial Efficacy for Clostridium difficile Infection. Front Microbiol. 2019 May 24;10:1141.

5. Wang JC, Chi SW, Shieh DB, Chuang HS* (2019 Jan). Development of a self-driving biosensor based on diffusion for simple detection of microorganisms. Sensors and Actuators: B- Chemical, 278,104-146. (SCI)

6. Huang KJ, Wei YH, Chiu YC, Wu SR, Shieh DB*. (2019 Mar) Assessment of zero-valent iron-based nanotherapeutics for ferroptosis induction and resensitization strategy in cancer cells. Biomater Sci.;7(4):1311-1322. doi: 10.1039/c8bm01525b

7. Nguyen TMT, Wang PW, Hsu HM, Cheng FY, Shieh DB*, Wong TY*, Chang HJ*(2019 Apr). Dental Cement’s Biological and Mechanical Properties Improved by ZnO Nanospheres. Materials Science & Engineering C: Materials for Biological Applications, 97,116-123.

8. Lin KY, Chung CH, Ciou JS, Su PF, Wang PW, Shieh DB*, Wang TC*. (2019 Jan) Molecular Damage and Responses of Oral Keratinocyte to Hydrogen Peroxide. BMC Oral Health, 19(1):10. doi: 10.1186/s12903-018-0694-0.

9. Wu YN*, Shieh DB, Yang LX, Sheu HS, Zheng RK, Thordarson P, Chen DH, Braet F(2018 Dec). Characterisation of Iron Core–Gold Shell Nanoparticles for Anti-Cancer Treatments: Chemical and Structural Transformations During Storage and Use. Materials, 17;11(12). pii: E2572. doi: 10.3390/ma11122572.

10. Hong WE, Hsu IL, Huang SY, Lee CW, Ko H, Tsai PJ, Shieh DB, Huang CC*(2018 Sep). Assembled growth of 3D Fe3O4@Au nanoparticles for efficient photothermal ablation and SERS detection of microorganisms. Journal of Materials Chemistry B, 6(36), DOI: 10.1039/c8tb00599k. (SCI)

11. Liu CC, Wu SC, Wu SR, Lin HY, Guo MS, Yung-Chih Hu A, Chow YH, Chiang JR, Shieh DB, Chong P(2018 May). Enhancing enterovirus A71 vaccine production yield by microcarrier profusion bioreactor culture. Vaccine, 36(22), 3134-3139. (SCI)

12. Wu PC, Shieh DB, Hsiao HT, Wang JCF, Lin YC, Liu YC. Magnetic field distribution modulation of intrathecal delivered ketorolac iron-oxide nanoparticle conjugates produce excellent analgesia for chronic inflammatory pain. J Nanobiotechnology. 2018 May 16;16(1):49.

13. Chiang WF, Cheng TM, Chang CC, Pan SH, Changou CA, Chang TH, Lee KH, Wu SY, Chen YF, Chuang KH, Shieh DB, Chen YL, Tu CC, Tsui WL, Wu MH. Carcinoembryonic antigen-related cell adhesion molecule 6 (CEACAM6) promotes EGF receptor signaling of oral squamous cell carcinoma metastasis via the complex N-glycosylation. Oncogene. 2017 Sep 11

14. Lee WT, Wu YN, Chen YH, Wu SR, Shih TM, Li TJ, Yang LX, Yeh CS, Tsai PJ, Shieh DB. Octahedron Iron Oxide Nanocrystals Prohibited Clostridium difficile Spore Germination and Attenuated Local and Systemic Inflammation. Sci Rep. 2017 Aug 15;7(1):8124.

15. Wu PC, Hsiao HT, Lin YC, Shieh DB, Liu YC. The analgesia efficiency of ultrasmall magnetic iron oxide nanoparticles in mice chronic inflammatory pain model. Nanomedicine. 2017 Aug;13(6):1975-1981. doi: 10.1016/j.nano.2017.05.005. Epub 2017 May 21.

16. Liu CC, Wu SC, Wu SR, Lin HY, Guo MS, Yung-Chih Hu A, Chow YH, Chiang JR, Shieh DB, Chong P. Enhancing enterovirus A71 vaccine production yield by microcarrier profusion bioreactor culture. Vaccine. 2017 Mar. pii: S0264-410X(17)30245-1.

17. Brink KS, Chen YC, Wu YN, Liu WM, Shieh DB, Huang TD, Sun CK, Reisz RR. Dietary adaptions in the ultrastructure of dinosaur dentine. J R Soc Interface. 2016 Dec;13(125).

18. Tsung-Ju Li, Chen-Min Chang, Po-Yang Chang, Yu-Chun Chuang, Chih-Chia Huang, Wu-Chou Su and Dar-Bin Shieh. Handheld energy efficient magneto-optical real-time quantitative polymerase chain reaction device for target DNA enrichment and quantification. NPG Asia Materials. 2016 June; 8, e277

19. Liu CC, Guo MS, Wu SR, Lin HY, Yang YT, Liu WC, Chow YH, Shieh DB, Wang JR, Chong P. Immunological and biochemical characterizations of coxsackievirus A6 and A10 viral particles. Antiviral Res. 2016 May;129:58-66.

20. Wang JC, Ku HY, Shieh DB, Chuang HS. A bead-based fluorescence immunosensing technique enabled by the integration of Förster resonance energy transfer and optoelectrokinetic concentration. Biomicrofluidics. 2016 Jan 28;10(1):014113.

21. Hwu JR, Tsay SC, Chuang KS, Kapoor M, Lin JY, Yeh CS, Su WC, Wu PC, Tsai TL, Wang PW, Shieh DB. Syntheses of Platinum-Sulindac Complexes and Their Nanoparticles as Targeted Anticancer Drugs. Chemistry. 2016 Feb;22(6):1926-1930.

22. Chen ZY, Wang PW, Shieh DB, Chiu KY, Liou YM. Involvement of gelsolin in TGF-beta 1 induced epithelial to mesenchymal transition in breast cancer cells. J Biomed Sci. 2015 Oct 20;22:90.

23. Tu LC, Wu MC, Chiang YP, Li HY, Shieh DB, Chang CC. What's New in the Treatment of Poor Levator Function with Severe Blepharoptosis. Plast Reconstr Surg. 2015 Oct;136(4 Suppl):100.

24. Kong B, Tsuyoshi H, Orisaka M, Shieh DB, Yoshida Y, Tsang BK. Mitochondrial dynamics regulating chemoresistance in gynecological cancers. Ann N Y Acad Sci. 2015 Sep;1350:1-16.

25. Shen YF, Tsai MR, Chen SC, Leung YS, Hsieh CT, Chen YS, Huang FL, Obena RP, Zulueta MM, Huang HY, Lee WJ, Tang KC, Kung CT, Chen MH, Shieh DB, Chen YJ, Liu TM, Chou PT, Sun CK. Imaging Endogenous Bilirubins with Two-Photon Fluorescence of Bilirubin Dimers. Anal Chem. 2015 Aug 4;87(15):7575-82.

26. Su PY, Wang YF, Huang SW, Lo YC, Wang YH, Wu SR, Shieh DB Chen SH, Wang JR, Lai MD, Chang CF (2015 Apr). Cell surface nucleolin facilitates enterovirus 71 binding and infection. J Virol, 15;89(8):4527-38.

27. Chen YC, Lee SY, Wu YN, Brink K, Sheieh, DB, Huang TD, Reisz RR, Sun CK (2015 Apr). Third-harmonic generation microscopy reveals dental anatomy in ancient fossils. Optics Letters, 40, 7, pp. 1354-1357.

■Review Papers, Book and Book Chapters

1. Nioka S, Shnall M, Conant E, Wang SC, Reynolds VB, Ching BC, Swan JHT, Chung PC, Cheng L, Shieh DB, Lin YC, Chung CH, Tseng SH, Britton C (2013 Edition). Chapter 29: Breast Cancer Detection of Large Size to DCIS by Hypoxia and Angiogenesis Using NIRS. Oxygen Transport to Tissue XXXV(book title, part IV). Advances in Experimental Medicine and Biology( series title), 789, pp.211-219. (DOI 10.1007/978-1-4614-7411-1_29)

2. Cheng D, Mitchell DRG, Shieh DB, Braet F (2012 Edition). Practical Considerations in the Successful Preparation of Specimens for Thin-Film Cryo-Transmission Electron Microscopy. Current Microscopy Contributions to Advances in Science and Technology (Microscopy book series No. 5), Vol. 2, pp.880-890.

3. Li YY(李映瑩), Tsai TL(蔡宗霖), Shieh DB*(謝達斌).人造標靶性光激發之奈米基因剪技術/ Artificial, Targeted, Light-Activated Nanoscissor for Sequence Selective Gene Scission. Instruments Today(科儀新知), Vol. 33(6), pp.16–25 , 2012 Jun.

4. Wu PC, Wang CRC, Li PC, Shieh DB*. Biological Stealth Gold nanorod platform based molecular photoacoustic imaging (金奈米生物隱形探針於光聲造影上的應用). Taiwan Nano Newsletter (台灣奈米會刊) , Vol. 19, pp. 44-51 , 2010 Jan.

5. Jeng YR, Mao CP, Shieh DB*. 細胞機械特性如何影響組織生理效應/The influence of biophysics to the physiology of the cells and tissues. Instruments Today(科儀新知), Vol. 31(4), pp. 57-63, 2010 Feb.

6. Shieh DB*, Lee YY, Tsai TL, Yeh CS. The application of Gold nanoparticles in Biomedicine. (金奈米粒子於生物醫學上的應用). 化學 Chemistry-奈米生醫材料專輯報導(中國化學會化學季刊), Vol. 68(1), pp. 11-20, 2010 Mar.

7. Shieh DB*, Li PC, Wang CRC. Nanoprobe Opens New Era in Photoacoustic Medicine (奈米探針開創光聲醫療). Scientific America Chinese Edition (科學人, ISSN:1682-2811), Vol. 86, pp. 102-105, 2009 Apr.

8. 吳炳慶、謝達斌(民96)，奈微米生醫晶片(專論)，“生醫奈米科技”，教育部「生物及醫學科技人才培育先導型計畫」，生醫奈米科技教學資源中心主編，11月初版，pp183-194.

9. 吳炳慶、謝達斌(民96)，生醫奈米的科技產業觀(專論)，“生醫奈米科技”，教育部「生物及醫學科技人才培育先導型計畫」，生醫奈米科技教學資源中心主編，11月初版，pp224-234.

10. 張佑民、謝達斌(民96)，奈米粒子的體外毒性測試(實驗)，“生醫奈米科技”，教育部「生物及醫學科技人才培育先導型計畫」，生醫奈米科技教學資源中心主編，11月初版，pp295-297.

11. 謝達斌、楊鏡堂、楊宗翰、方偉峰(民96)，微流體生物晶片實作與應用(實驗)，“生醫奈米科技”，教育部「生物及醫學科技人才培育先導型計畫」，生醫奈米科技教學資源中心主編，11月初版，pp304-322.

12. 謝達斌(民94, 2008)，奈米生醫(應用篇)，“奈米科技－基礎、運用與實作”，南區奈米科技K-12教育發展中心，丁志明等編著，高立出版，pp321-340, ISBN: 9789864122257.

13. 傅昭銘、謝達斌(民94, 2008)，奈米顆粒生醫應用(實作篇)，“奈米科技－基礎、運用與實作”，南區奈米科技K-12教育發展中心，丁志明等編著，高立出版，pp373-380, ISBN: 9789864122257.

14. Shieh DB(1997), Molecular Genetic Features Affecting The Prognosis in Stage I Non-Small-Cell Lung Cancer: activating mutations of K-Ras; loss of heterozygosity at sites on 3p, 5q, 8p, 9p, 11p, and 17p; and expression of cell-motility-related proteins. D.M.Sc. thesis.